Function | Mechanism | Diseases
What we do
Efforts to understand the genetic and molecular interactions contributing to the development and progression of diseases have focused mostly on protein coding genes, leaving the noncoding genome vastly under-explored. We now know that a large fraction of these noncoding regions are transcribed, generating thousands of long RNAs that do not encode proteins (lncRNAs). These lncRNAs are expressed with exquisite tissue specificity and several have been found to regulate diverse regulatory processes. Accumulating evidence also point to lncRNA loci as risk factors frequently deregulated or mutated in a wide variety of human diseases. However, whether lncRNAs contribute to the establishment or progression of diseases in vivo and how they may affect transcriptional programs and signaling pathways still remains poorly characterized. Thus, one of the main challenge to understand the noncoding genome’s influence on human health is not only to determine which lncRNAs are functional, but also to decipher how they perform their tasks and affect the pathophysiology of diseases.
Our laboratory takes advantage of human genetics data to identify lncRNAs in disease risk genomic regions. We combine genetically engineered mouse models and human cellular systems with functional genomics and CRISPR-based genome editing techniques to perturb lncRNA functions and characterize their role at a cellular and physiological level. We also aim to uncover novel noncoding RNA-based mechanisms by characterizing the molecular interactions and regulatory principles underlying the function of lncRNAs. For this, we use a combination of biochemistry, genome editing, computational and high-throughput genomics approaches to identify interacting proteins and understand how specific domains or RNA sequences within lncRNAs mediate their function.
Our goal is to better understand the impact that lncRNAs and noncoding regions have on human health and diseases and provide much needed genetics and molecular bases towards the development of novel diagnostics and RNA-targeting therapeutics.
Thanks to these agencies for funding our research
Martin Sauvageau Laboratory
Functional Genomics and Noncoding RNAs Research Unit
The Montreal Clinical Research Institute is not responsible for the content of this website.
L'Institut de Recherches Cliniques de Montréal n'est pas responsable du contenu de ce site web.
Meet The Team
Martin Sauvageau, PhD
Director, Laboratory of RNA and Noncoding Disease Mechanisms, IRCM
Assistant Professor, Biochemistry & Molecular Medicine Department, UdeM
Senior Research Associate, Institute for RNA Medicine, Harvard Medical School
Postdoc: Stem Cell & Regenerative Medicine, Harvard University
PhD, Institute for Research in Immunology & Cancer (IRIC), McGill University
BSc, Université de Montréal
David Ferland-McCollough, PhD
Sr Research Associate, University Bristol
Postdoc, MRC Toxicology unit, Leicester
Postdoc, Nottingham University
PhD, Université de Nantes
MSc, Université de Montréal
BSc, McGill University
Marie-Ève Wedge, MSc
MSc, University of Ottawa
BSc, Université Laval
We're always looking for motivated and talented people.
Interested in the lab and want to join? Get in touch!
If you're interested in joining the Sauvageau lab, please send a motivation letter, CV, 2 reference letters and a copy of your full University transcripts (for graduate students applicants only) to firstname.lastname@example.org.
Selected candidates will be contacted for an interview.
Not recruiting at the moment