Copyright © Martin Sauvageau. All rights reserved.

Function  |  Mechanism  |  Diseases

What we do

Efforts to understand the genetic and molecular interactions contributing to the development and progression of diseases have focused mostly on protein coding genes, leaving the noncoding genome vastly under-explored. We now know that a large fraction of these noncoding regions are transcribed, generating thousands of long RNAs that do not encode proteins (lncRNAs). These lncRNAs are expressed with exquisite tissue specificity and several have been found to regulate diverse regulatory processes. Accumulating evidence also point to lncRNA loci as risk factors frequently deregulated or mutated in a wide variety of human diseases. However, whether lncRNAs contribute to the establishment or progression of diseases in vivo and how they may affect transcriptional programs and signaling pathways still remains poorly characterized. Thus, one of the main challenge to understand the noncoding genome’s influence on human health is not only to determine which lncRNAs are functional, but also to decipher how they perform their tasks and affect the pathophysiology of diseases.

 

Our laboratory takes advantage of human genetics data to identify lncRNAs in disease risk genomic regions. We combine genetically engineered mouse models and human cellular systems with functional genomics and CRISPR-based genome editing techniques to perturb lncRNA functions and characterize their role at a cellular and physiological level. We also aim to uncover novel noncoding RNA-based mechanisms by characterizing the molecular interactions and regulatory principles underlying the function of lncRNAs. For this, we use a combination of biochemistry, genome editing, computational and high-throughput genomics approaches to identify interacting proteins and understand how specific domains or RNA sequences within lncRNAs mediate their function.

 

Our goal is to better understand the impact that lncRNAs and noncoding regions have on human health and diseases and provide much needed genetics and molecular bases towards the development of novel diagnostics and RNA-targeting therapeutics.

Thanks to these agencies for funding our research

Martin Sauvageau Laboratory

Functional Genomics and Noncoding RNAs Research Unit

The Montreal Clinical Research Institute is not responsible for the content of this website.

L'Institut de Recherches Cliniques de Montréal n'est pas responsable du contenu de ce site web.

 
 

Meet The Team

Martin Sauvageau, PhD

Director, Functional Genomics & Noncoding RNA Laboratory, IRCM

Assistant Professor, Biochemistry & Molecular Medicine, UdeM

  • Senior Research Associate, Institute for RNA Medicine, Harvard Medical School

  • Postdoc: Stem Cell & Regenerative Medicine, Harvard University

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  • PhD, Institute for Research in Immunology & Cancer (IRIC), McGill University

  • BSc, Université de Montréal

Sahar Mikaeeli

Graduate Student (co-supervised)

  • BSc, Islamic Azad University, Iran

Mariana Correro

Administrative Assistant

Sophie Ehresmann, MSc

Graduate Student

  • MSc, Université de Montréal 

  • BSc, Université de Montréal

Jean-François Laurendeau

Graduate Student

  • BSc, Université de Montréal

David Ferland-McCollough, PhD

Research Associate

  • Sr Research Associate, University Bristol

  • Postdoc, MRC Toxicology unit, Leicester

  • Postdoc, Nottingham University

  • PhD, Université de Nantes

  • MSc, Université de Montréal 

  • BSc, McGill University

Marie-Ève Wedge, MSc

Research Assistant

  • MSc, University of Ottawa 

  • BSc, Université Laval

 

Selected Publications

For a complete list of publications please click here. 

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. (2018) 173:649-664.e20.

Groff AF, Sanchez-Gomez DB, Soruco MML, Gerhardinger C, Barutcu AR, Li E, Elcavage L, Plana O, Sanchez LV, Lee JC, Sauvageau M, Rinn JL. Cell Reports. (2016) 16:2178-2186.

*Goff LA, *Groff AF, *Sauvageau M, Trayes-Gibson Z, Sanchez-Gomez DB, Morse M, Martin RD, Elcavage LE, Liapis SC, Gonzalez-Celeiro M, Plana O, Li E, Gerhardinger C, Tomassy GS, Arlotta P, Rinn JL. PNAS. (2015) 112:6855-62.

Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Nature Struct Mol Biol. (2014) 21:198-206.

Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL. eLife. (2013) 2:e01749.

Sun L, Goff LA, Trapnell C, Alexander R, Lo KA, Hacisuleyman E, Sauvageau M, Tazon-Vega B, Kelley DR, Hendrickson DG, Yuan B, Kellis M, Lodish HF, Rinn JL. PNAS. (2013) 110:3387-92.

Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L. Nature Biotech. (2013) 31:46-53.

*Trost M, *Sauvageau M, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P. Blood. (2012) 120(8):e17-27.

Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S, Boucher G, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavallée S, Sauvageau M, Hébert J, Sauvageau G. Genes & Development. (2012) 26:651-6.

Sauvageau M, Sauvageau G. Cell Stem Cell. (2010) 7:299-313.

Sauvageau M, Miller M, Lemieux S, Lessard J, Hébert J, Sauvageau G. Blood. (2008) 111:790-9.

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Join Us

We're always looking for motivated and talented people.

Interested in the lab and want to join? Get in touch!

Jobs

If you're interested in joining the Sauvageau lab, please send a motivation letter, CV, 2 reference letters and a copy of your full University transcripts (for graduate students applicants only) to martin.sauvageau@ircm.qc.ca.

 

Selected candidates will be contacted for an interview.

Positions:

Postdoctoral Fellows:

Position Available

 

Graduate Students:

Not recruiting at the moment

 
 

Contact Us

Functional Genomics and Noncoding RNAs

Montreal Clinical Research Institute - IRCM

110 Avenue des Pins Ouest, Rm 2690

Montreal, QC, Canada H2W 1R7

Lab:    (514) 987-5654

Office: (514) 987-5599