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RNA Therapeutics Core

Scientific Director: Dr. Martin Sauvageau

Core Director: Dr. Alireza Omumi

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Antisense Oligos (ASO)

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siRNAs

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mRNA

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LNP

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In vitro Screening

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In vivo Validation

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Research

Facility Equipment

The IRCM RNA Therapeutics Core is equipped with state-of-the-art instruments to manufacture pre-clinical grade ASO, siRNA, mRNA, and LNP through fee-for-service or co-development opportunities. Our goal is to provide academic researchers and industrial partners with access to technologies and expertise to support and accelerate their discoveries.

Oligonucleotide (ASO/siRNA/sgRNA) Synthesis

• Sequence Design & Experimental Consultation

Equipment

• Synthesis Scale: 2 nmol to 100 µmol

• Modifications:

Phosphodiester (PO)
Phosphorothioate (PS)
Mesyl-phosphoramidate (MsPA)
Morpholino (PMO)
Locked Nucleic Acid (LNA)
Peptide Nucleic Acid (PNA)
2'-O-Methyl (OMe)
2'-O-Methoxyethyl (MOE)
2'-Fluoro (F)
Constrained Ethyl (cEt)
5-methylcytosine (5mC)
Other Custom Modifications

Shimadzu HPLC LC-MS

• Conjugation:

GalNAc
Antibody Oligo Conjugate (AOC)
Peptide Oligo Conjugate (POC)
Other Small Molecules & Linkers

Sierra Biosystem
Shasta 96/192
High-throughput Oligo Synthesizer

RNA Synthesis

• Sequence Design & Experimental Consultation

• Synthesis Scale: 50 µg to 20 mg

• Modifications:

N1-Methylpseudouridine (m1-PsU )
Pseudouridine (PsU)
5-Methylcytosine (5mC)

• Cap:

CleanCap M6
CleanCap AG 3'OMe
CleanCap AG
CleanCap AU
Co Cap A
ARCA

Lipid Nanoparticles Formulation

Screening & Testing

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